Classification and Comparison of Early-onset and Late-onset Idiopathic Chronic Pancreatitis

Naval Military Medical University

Status: Unknown

Conditions: Chronic Pancreatitis; Idiopathic Chronic Pancreatitis

Study type: Observational

Funder types: Other

Identifiers

NCT03953937

ICP-1

Details and patient eligibility

About

Classification of early-onset idiopathic chronic pancreatitis (EOICP) and late-onset idiopathic chronic pancreatitis (LOICP) was proposed based on bimodal distribution of age at onset of idiopathic chronic pancreatitis (ICP). However, studies of larger populations prove it may be normal distribution. Therefore, the aim of the study is to find what the distribution of age at onset of ICP is and whether the classification of EOICP and LOICP is meaningful.

Full description

Idiopathic chronic pancreatitis (ICP) patients admitted to the investigator's center from January 2000 to December 2013 were enrolled. Characteristics were compared between early-onset idiopathic chronic pancreatitis (EOICP) and late-onset idiopathic chronic pancreatitis (LOICP) patients. Cumulative rates of diabetes mellitus, steatorrhea, pancreatic stone, pancreatic pseudocyst (PPC), biliary stricture, and pancreatic cancer after the onset and the diagnosis of ICP were calculated, respectively. Different cut-off values for age at onset of ICP were set to classify EOICP and LOICP. Then differences of clinical courses between EOICP and LOICP were compared when classified by distinct cut-off values.

Enrollment: 1,633 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed with idiopathic chronic pancreatitis according to Asia-Pacific consensus

Exclusion criteria

• Pancreatic cancer diagnosed within 2 years after the diagnosis of chronic pancreatitis
• Groove pancreatitis
• Autoimmune pancreatitis
• Chronic pancreatic patients with identified etiologies

Trial design

1,633 participants in 1 patient group

ICP cohort

Description:

Patients with idiopathic pancreatitis