Classification of Carotid Plaque With Computed Tomography With Fast kVp (Kilovolt Peak)-Switching Technique

Karolinska Institute

Status: Completed

Conditions: Carotid Stenosis; Atherosclerosis

Treatments: Other: Carotid endarterectomy in clinical healthcare.

Study type: Observational

Funder types: Other

Identifiers

NCT02436967

SN 020 DECTA

Details and patient eligibility

About

Classification of carotid plaque vessel wall changes in carotid stenosis accordingly to AHA classification (American Heart Association)- comparison between histology and CT. The CT is performed with a fast kVp-switching dual energy technique.

To compare the ability to detect iodine contrast enhancement in the carotid plaque compared with 3T MRI with gadolinium.

Full description

Patients planned for CEA (carotid endarterectomy) due to carotid stenosis will be examined with one extra CT and MRI before surgery. The CEA specimen is stored in the BiKE-registry (a biobank of operated carotid plaque at the Karolinska Institute). In that registry the patients will be given a personal code which is used to identify the CT, MRI and histology data further on.

Approved by regional ethical review board in Stockholm and local radiation comity at Karolinska University Hospital Solna (Dnr K2435-2014). Informed consent from the participating patients.

Enrollment: 31 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 50% stenosis (NASCET) or more based on CTA (CT-angiography),
• MRI or US,
• Scheduled for CEA
• 50 years or older,
• Normal kidney function (estimated GFR (glomerular filtration rate) 60 ml/min or more).

Exclusion criteria

• Contraindications to iodine contrast media,
• Contraindications to MRI or gadolinium contrast media.