Classification of Heart Failure With Preserved Ejection Fraction

Northwestern University logo

Northwestern University

Status

Completed

Conditions

Diastolic Heart Failure
Heart Failure With Preserved Ejection Fraction

Study type

Observational

Funder types

Other

Identifiers

NCT01030991
AHA 0835488N

Details and patient eligibility

About

The purpose of this study is to create a classification system for the heterogenous disorder of heart failure with preserved ejection fraction (HFpEF).

Full description

Patients with HFpEF are a heterogeneous group with varying etiology and pathophysiology, which may play a large role in the difficulty in managing these patients and enrolling them in clinical trials. A major advance in the care of patients with HFpEF would be a classification system based on etiology, pathophysiology, and/or genetic factors as well as machine learning analyses. The ultimate goal of this study is to demonstrate that it is possible to better classify patients with HFpEF based on etiologic, pathophysiologic, and genetic differences between patients. If successful, this study could lead to: (1) novel risk estimation in patients with HFpEF and (2) more fruitful clinical trials based on targeting specific subsets of HFpEF.

Enrollment

514 patients

Sex

All

Ages

21+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age > 21 years
  • Signs or symptoms of congestive heart failure
  • Left ventricular ejection fraction > 50%

Exclusion criteria

  • Severe valvular heart disease
  • History of cardiac transplantation
  • Prior history of heart failure associated with left ventricular ejection fraction < 35%

Trial design

514 participants in 1 patient group

HFpEF
Description:
HFpEF cohort (observational study)

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems