CLDN18.2 Targeting PET Imaging in Patients With Gastrointestinal Tumors

Peking University Cancer Hospital & Institute

Status: Active, not recruiting

Conditions: Gastrointestinal Cancer

Treatments: Other: 124I-18B10(10L) PET/CT

Study type: Interventional

Funder types: Other

Identifiers

NCT04883970

2021KT57

Details and patient eligibility

About

The objective of the study is to constrcut a noninvasive approach 124I-18B10(10L) PET/CT to detect the CLDN18.2 expression of tumor lesions in patients with gastrointestinal tumors and to identify patients benefiting from CLDN18.2 targeting treatment.

Enrollment: 15 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Aged >18 years old; ECOG 0 or 1;
• 2. Patients with Gastrointestinal tumors;
• 3. Has at least one measurable target lesion according to Response Evaluation Criteria in Solid Tumors (RECIST V1.1);
• 4. life expectancy >=12 weeks.

Exclusion criteria

• 1. Significant hepatic or renal dysfunction;
• 2. Is pregnant or ready to pregnant;
• 3. Cannot keep their states for half an hour;
• 4. Refusal to join the clinical study;
• 5. Suffering from claustrophobia or other mental diseases;
• 6. Any other situation that researchers think it is not suitable to participate in the experiment.

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Imaging cohort

Experimental group

Description:

All study participants will be allocated to this arm (single-arm study). Study participants will undergo 124I-18B10(10L) PET/CT scans

Treatment:

Other: 124I-18B10(10L) PET/CT