Clear Cell Chondrosarcoma in Italy (CIRCLE)

Istituto Ortopedico Rizzoli

Status: Active, not recruiting

Conditions: Chondrosarcoma

Treatments: Genetic: Molecular studies

Study type: Interventional

Funder types: Other; NETWORK

Identifiers

NCT07360964

CIRCLE

Details and patient eligibility

About

Clear cell chondrosarcoma of bone is considered a low-grade malignant tumor in the last WHO classification of soft tissue and bone tumors; however, it is reported that recurrences and metastasis can occur. Considering the uncertain prognosis of this rare tumor, with some cases that historically seems to pursue a bad prognosis, we decided to collect all the Italian cases of clear cell condrosarcoma, in order to better understand its natural history and prognosis.

Enrollment: 77 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male and female patients with diagnosis of clear cell chondrosarcoma and chondrosarcoma with a clear cell component treated from 01 Jan 1982 to 31 Dec 2023
• Information available (date of primary tumor diagnosis, local treatments, systemic treatment, response to systemic treatment, date of progression) and date and status at last follow-up
• Imaging studies available for revision
• Histological slides available for revision

Exclusion criteria

• - Diagnosis different from clear cell chondrosarcoma or chondrosarcoma with a clear cell component;
• Absence of radiological and/or clinical data

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

77 participants in 1 patient group

Patients

Experimental group

Description:

Patients with a diagnosis of clear cell chondrosarcoma

Treatment:

Genetic: Molecular studies