Clevidipine in Neurocritical Patients (NEURO-CLEV)

Cruces University Hospital

Status: Completed

Conditions: High Blood Pressure

Treatments: Drug: Clevidipine 0.5 MG/ML Intravenous Emulsion

Study type: Observational

Funder types: Other

Identifiers

NCT05168059

CEIC E19/17

Details and patient eligibility

About

Acute blood pressure elevation is a frequent problem in neurocritical patients. Its effective management is challenging and must avoid significant decreases of blood pressure leading to lower cerebral perfusion pressure worsening ischemia and elevations probably associated with bleeding, rebleeding or hematoma expansion associated with poor prognosis

Full description

Retrospective, observational and single-group study for observe effectiveness and safety of clevidipine for perioperative control of hypertension in patients admitted to Post-Operative Intensive Care Unit after thrombectomy for stroke, intracerebral hemorrhage requiring surgical treatment, embolization of aneurysm after subarachnoid hemorrhage, scheduled neurosurgical and neuroradiology procedures.

Enrollment: 33 patients

Sex

Volunteers: No Healthy Volunteers

Inclusion criteria

1. -Adult patients older than 18 years old admitted to Post-Operative Intensive Care Unit with neurocritical condition requiring surgical or interventional treatment.
2. -Acute High Blood Pressure requiring urgent treatment (SBP ≥160 mmHg or ≥ 20% increase in preoperative values that persists for more than 15 minutes)
3. -Clevidipine used as a first line or after failure of different antihypertensive drugs.

Exclusion criteria

1. -Adults older than 90 years admitted to Post-Operative Intensive Care Unit with neurocritical condition requiring surgical or interventional treatment.
2. -Patients admitted to Post-Operative Intensive Care Unit with neurocritical condition not requiring surgical or interventional treatment.