CLIC1 in Patients Presenting PD

Seoul National University

Status: Completed

Conditions: Hip Fractures; Hip Disease

Treatments: Procedure: Hip surgery; Behavioral: Perioperative delirium

Study type: Observational

Funder types: Other

Identifiers

NCT05446181

B-2109-706-302

Details and patient eligibility

About

In this study, mononuclear cells, particularly monocytes, were collected from the peripheral blood of elderly patients who underwent orthopedic hip surgery under spinal anesthesia. We then observe the accumulation of chloride intracellular channel 1 (CLIC1), particularly the characteristic accumulation morphology and its function. The purpose of this study is to compare whether there is a difference in the degree and form of cytoplasmic CLIC1 accumulation between the elderly group with postoperative delirium (PD) and the elderly group without postoperative delirium. We'll also confirm whether this is appropriate as a predictor of postoperative delirium. In addition, we will establish a control group for the non-elderly group to check the difference due to aging itself.

Enrollment: 62 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Male or female patients aged 65 years or older who are scheduled to undergo surgery for an orthopedic hip fracture under spinal anesthesia

Exclusion criteria

• Patients who are unconscious
• Patients who are unable to communicate
• Alzheimer
• Parkinson Disease
• Conversion to general anesthesia

Trial design

62 participants in 2 patient groups

Old with perioperative delirium

Treatment:

Behavioral: Perioperative delirium

Procedure: Hip surgery

Old without perioperative delirium

Treatment:

Procedure: Hip surgery