Clifutinib Food Effect Study in Healthy Subjects

Sunshine Lake Pharma

Status and phase

Completed

Phase 1

Conditions

Acute Myeloid Leukemia in Children

Treatments

Drug: Clifutinib with fed state

Drug: Clifutinib with fasted state

Study type

Interventional

Funder types

Industry

Identifiers

HEC73543-AML-103

Details and patient eligibility

About

The purpose of this study is to evaluate to determine the effect of food on the PK of a single dose of 40 mg Clifutinib in healthy subjects.

Enrollment

40 patients

Sex

All

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy subjects (male or female), age greater than or equal to 18 years and less than or equal to 45 years;
Weight ≥50 kg (≥45 kg for female), and have a body mass index (BMI) between 18 and 28 (including 18 and 28) at screening;
Physical examination, clinical laboratory examination and other related examinations are normal or acceptable deviations that are judged to be not clinically significant by the investigator;
Male or female subjects with child-bearing potential must agree to use effective contraception during the study and within 6 months after the administration of the last dose, and sperm donation is not allowed for male subjects during the study; female subjects must be non-pregnant and non-lactating；
Volunteer to participate in this study, understand the study procedures and sign the informed consent prior to any study specific procedures, good compliance and willing to follow study procedures.

Exclusion criteria

Have a history of or current cardiovascular, respiratory, hematological, hepatic, renal, gastrointestinal, endocrine, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs;
Unable to tolerate standard meals;
Prolonged QT interval corrected for heart rate using Fridericia's formula (QTcF) >470 ms (female >480 ms), or history of long QT syndrome；
Have received live vaccine(s) within 3 months prior to screening;
Have used over-the-counter or prescription medication , including herbal medications, within 14 days prior to dosing and during the study;
Have known allergy to any drug or food;
Smoking more than 5 cigarettes per day (or equivalent in tobacco or nicotine products) within 3 months prior to screening, or unwilling to abide by smoking restrictions during the study;
Any positive result on screening for serum hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody ,human immunodeficiency virus (HIV) antibody or Treponema pallidum antibody;
Known history of drug abuse