Climat Impact on Urinary Iodine Concentration (LION)

Federal Institute of Technology (ETH) Zurich

Status

Completed

Conditions

Iodine Deficiency

Treatments

Other: Climate

Study type

Observational

Funder types

Other

Identifiers

NCT03215680

LION

Details and patient eligibility

About

Urinary iodine concentration (UIC) is the recommended biomarker of iodine status in populations. Yet, the influence of climate on UIC remains unclear. Hot climate may reduce urine volume and consequently increase UIC independent of iodine status. This could lead to an overestimation of population iodine intake, thus masking iodine deficiency in vulnerable groups.

In this longitudinal observational cohort study in women of reproductive age we will collect 24h and spot urine samples in the summer and winter season. The influence of high temperature climates on UIC, measured and estimated urinary iodine excretion will be estimated.

Enrollment

363 patients

Sex

Female

Ages

18 to 49 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Female
Non-pregnant and non-lactating
General good health, assessed by no reported treatment for chronic disease
Non-smoking
No known history of major medical illnesses or thyroid dysfunction as well as gastrointestinal or metabolic disorders and taking no chronic medication
Residence at the respective study site for 12 months or longer and no plans of moving away during the study year.
No use of iodine containing dietary supplements during the last 6 months
No use of X-ray / CT contrast agent or iodine containing medication within the last year
No use of iodine containing disinfectants during the last 6 months
Participants should be between 18 and 49 years at date of enrollment