Clinic and Neurophysiology of Aphasia Treatment (AphasRehab)

Klinik Bavaria

Status: Not yet enrolling

Conditions: Aphasia, Acquired

Treatments: Behavioral: CIAT + Conventional neurorehabilitative therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05572385

EK-BR-157/20-1

Details and patient eligibility

About

In the planned study, clinical and electrophysiological features of aphasia recovery in stroke patients are investigated.

Full description

Clinical neurorehabilitation faces a major challenge of functional recovery in aphasia, i.e. guiding the structural and temporal dynamics of reorganization within responsible neural networks. Here, according to current research, relevant neural factors affecting the treatment and thus the functional recovery of aphasia patients after stroke are of interest, highlighting structural as well as functional neuroanatomical features. Of particular interest are not only the functional localization of affected cerebral regions, but more the clinical and neurophysiological patterns which might help to factorize and predict the therapeutic outcome. In the planned study, the clinical and neurophysiological characteristics of the dynamics of language function recovery in relation to the intensity of professional speech therapy (constraint induced aphasia therapie - CIAT) will be recorded in 40 patients with aphasia resulting from a cerebrovascular event. The aim of this study is to test the value of neurophysiological aspects based on electroencephalographic (EEG) parameters such as event-related potentials (N400, P600, theta band activity) for the identification of specific neuronal markers, which in turn support predictive statements for individual therapy planning of logopedic treatment in neurorehabilitation.

Enrollment: 40 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with a cerebrovascular event

Exclusion criteria

• premorbid brain disorder

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Patients with aphasia

Active Comparator group

Description:

Patients with a clinical aphasia (20 receptive, 20 expressive) with a specific logopedic treatment, with specific EEG measurement at start and end of treatment schedule.

Treatment:

Behavioral: CIAT + Conventional neurorehabilitative therapy

Patients without aphasia

No Intervention group

Description:

Patients with comparable stroke characteristics, but without clinical aphasia.