Clinical and Biochemical Effects of Multipass Hemodialysis (MHD)

Herlev Hospital

Status and phase: Completed; Phase 2

Conditions: Uremia

Treatments: Device: Multipass hemodialysis

Study type: Interventional

Funder types: Other

Identifiers

NCT01267760

mhd1

Details and patient eligibility

About

The purpose of this study is to investigate whether recycled dialysis fluid can supply enough clearance for hemodiaysis patients.

Full description

Conventional hemodialysis uses large amounts of water, which hinders travel possibilies for home hemodialysis (HD) patients. We have developed a recycling system using 25-30 l dialysate per dialysis. In vitro investigations show that this results in adequate dialysis.

12 HD patients will be studied during two dialysis sessions. The first HD will be a conventional 4 hour dialysis, using single pass dialysate. The second will be an 8-hour HD using multipass (recycled) dialysate 25-30 l. Clearance of urea, creatinine, phosphate and cobalamin will be measured both in the patient and the dialysate. Patient symptoms will be recorded.

Enrollment: 12 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stable chronic HD patients
• Informed consent

Exclusion criteria

• Age <18 years
• Psychiatric disease

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

12 participants in 1 patient group

conventional HD

Active Comparator group

Description:

conventional 4-hour HD

Treatment:

Device: Multipass hemodialysis