Clinical and Biochemical Evaluation of 1% Metformin in Non-surgical Treatment of Periodontitis

Ain Shams University

Status: Completed

Conditions: Periodontitis

Treatments: Drug: Placebo; Drug: Metformin

Study type: Interventional

Funder types: Other

Identifiers

NCT06204185

FD-ASUREC.IM011967

Details and patient eligibility

About

The aim of the study to evaluate the clinical and biochemical efficacy of 1% Metformin gel in treatment of periodontitis patients

Enrollment: 40 patients

Sex: All

Ages: 30 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with Stage III Grade A Periodontitis.
• Systemically free according to the modified Burkitt's health history questionnaire, Group I. (Glick et al., 2021).
• Good compliance with the plaque control instructions following initial therapy.
• Availability for follow up and maintenance program.

Exclusion criteria

• Smokers
• Pregnant and lactating females.
• Vulnerable groups of patients' e.g (prisoners, handicapped patients and decisionally impaired individuals).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

1% Metformin

Active Comparator group

Description:

1% Metformin Delivered in biodegradable gel. Frequency- One dose each at baseline, 3 months and 6 months.

Treatment:

Drug: Metformin

Control Group

Placebo Comparator group

Description:

Placebo gel without the active ingredient. Delivered in biodegradable gel. Frequency- One dose each at baseline, 3 months and 6 months.

Treatment:

Drug: Placebo