Clinical and Biological Markers of Response to Cognitive Behavioural Therapy for Depression

Center for Addiction and Mental Health (CAMH)

Status

Completed

Conditions

Depression

Treatments

Behavioral: Cognitive Behavioral Therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT02883257

003/2016

Details and patient eligibility

About

The purpose of this study is to locate clinical markers (for example, interviews, questionnaires, and computer tasks) and biological markers (for example, physiological, blood-based, or electroencephalography measurements) that predict response to cognitive behavioral therapy for depression.

Full description

Forty adult outpatients with major depressive disorder or persistent depressive disorder will receive up to 20 sessions of cognitive behavioral therapy for depression over 16 weeks. Participants will complete clinical measures (interviews, questionnaires, and computer-based tasks) and biological measures (blood tests, physiological measurements, electroencephalography ) before, during, and after treatment.

Enrollment

41 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Clinical diagnosis of Major Depressive Disorder or Persistent Depressive Disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
Must be fluent in English
Must be capable to give informed consent

Exclusion criteria

Lifetime diagnosis of Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
Current Alcohol or Drug Use Disorder (except tobacco or caffeine)
Current psychotic symptoms
Acute suicide risk
Psychological treatment for depression initiated during the past three months
Pharmacological treatment for depression initiated/changed during the past three months
Previous non-response to two or more adequate trials of pharmacotherapy
Current significant neurological disorder, head trauma, or unstable medical conditions.