Clinical and Economic Impact of an Electronic Medical Record Interfaced Decision Support System Reinforced With Patient Specific Pharmacogenetic Data for Minimizing Severe Drug-Drug Interactions (DDI+)

Leumit Health Services

Status: Completed

Conditions: Healthcare

Treatments: Other: DDI+ System and Pharmacogenetic Data

Study type: Interventional

Funder types: Other

Identifiers

NCT01765621

LHS022013

Details and patient eligibility

About

Leumit Health Services, an health maintenance organization operating in Israel, will incorporate a web-based, decision support system for handling drug-drug interactions and drug information, termed DDI+ reinforced with patient specific pharmacogenetic data. The investigators hypothesize that implementing such a system will reduce health-care expenditures (e.g., hospital admissions, referrals to ERs, Imaging procedures).

Enrollment: 973 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Number of chronic concomitant drugs ≥5
• treated with 1 or more drugs with a well established interaction with 1 or more of the following CYP450 enzymes: 2c9, 2c19, 2d6

Exclusion criteria

• Patients diagnosed with HIV/AIDS, and/or viral hepatitis B or C

Trial design

Primary purpose: Health Services Research

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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973 participants in 2 patient groups

DDI+ and Pharmacogenetic data

Experimental group

Description:

DDI+ System and Pharmacogenetic data

Treatment:

Other: DDI+ System and Pharmacogenetic Data

Standard Care

No Intervention group

Description:

Control