Clinical and Genetic Markers of Bone Metabolism in Children Under One Year

West Kazakhstan Medical University

Status: Enrolling

Conditions: Bone Remodeling Disorder; Child Development; Genetic Change

Study type: Observational

Funder types: Other

Identifiers

NCT05375331

777.04.12.2020

Details and patient eligibility

About

The study of children under one year of age for molecular genetic testing-VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) with the study of the frequency distribution of alleles and genotypes by polymorphisms, analysis of the relationship of molecular genetic markers with indicators of bone metabolism.

Full description

Children under the age of one year of Kazakh nationality born in Aktobe will be examined.

Each child included in the study will have an individual registration card, where information about the health status of the child and the health status of the mother during pregnancy will be filled in.

A biochemical analysis will be determined for the level of calcium, phosphorus, calcitonin, parathyroid hormone, osteocalcin, vitamin D in blood serum and deoxypyridinoline in urine.

Blood will be taken to determine the genetic polymorphism of VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759).

The state of bone tissue remodeling (osteocalcin, vitamin D, Ca, P, calcitonin, deoxypyridinoline) will be revealed The frequencies of allelic variants of the VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) genes in children under the age of one year in the population of Kazakhstan were determined.

Enrollment: 245 estimated patients

Sex: All

Ages: 1 day to 1 year old

Volunteers: No Healthy Volunteers

Inclusion criteria

-Children 0 -12 months old

Exclusion criteria

• Musculoskeletal system diseases;
• Severe chronic somatic diseases;
• Supplementation of vitamin D in a therapeutic dose;
• Lack of consent of the parents or legal representatives to participate in the study.