Clinical and Laboratory Assessment of Iron Overload in Sickle Cell Anemia and Sickle Cell Thalassemia

HaEmek Medical Center, Israel

Status: Completed

Conditions: Sickle Cell Thalassemia; Sickle Cell Anemia

Treatments: Other: Laboratory analyses of iron overload

Study type: Observational

Funder types: Other

Identifiers

NCT00512564

0087-07-EMC

Details and patient eligibility

About

Iron overload is well study in Thalassemia patients and it's not only related to blood transfusions, since intestinal iron absorption is also increased in those patients. Sickle cell patients didn't developed significant clinical symptoms and signs of iron overload in spite frequent transfusions. The purpose of this study is to assess the iron overload in Sickle cell anemia and Sickle cell Thalassemia patients using clinical parameters and laboratory studies including Non Transferrin Binding Iron, Labile Iron and Hepcidin, in order to determine the cardiac and liver iron.

Enrollment: 50 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• All the patients with Sickle Cell Anemia and Sickle Cell Thalassemia that are treated and followed up at the Pediatric Hematology Unit.

Trial design

50 participants in 1 patient group

1

Description:

Patients suffering from Sickle cell disease

Treatment:

Other: Laboratory analyses of iron overload