Clinical and Live Birth Rates After Following Long Antagonist Protocol Versus Long Agonist Protocol

Assisting Nature

Status

Unknown

Conditions

Pregnancy, Ovarian

Treatments

Diagnostic Test: Clinical Pregnancy Rate

Study type

Observational

Funder types

Other

Identifiers

NCT03693534

Long-Antagonist-AN005

Details and patient eligibility

About

A prospective study of the evaluation of the clinical IVF (in vitro fertilization) results after following Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus following Long Agonist protocol

Full description

A prospective study of the clinical results in women who followed the Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus women who followed Long Agonist protocol, in an In Vitro Fertilization (IVF) try. In particular, the Clinical Pregnancy Rates (CPR) and Live Birth Rates (LBR) were estimated for the two groups of patients. The number of the formed blastocysts was also measured in each group of patients.

Enrollment

120 estimated patients

Sex

Female

Ages

18 to 39 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

primary infertility
age 18-39 years; body mass index (BMI) 18-29kg/m2;
regular menstrual cycle of 26-35days,
presumed to be ovulatory;
early follicular- phase serum concentration of FSH within normal limits (1-12 IU/l).

Exclusion criteria

women with diabetes and other metabolic disease
women with heart disease, QT prolongation,heart failure
elevated liver enzymes, liver failure, hepatitis
women with inflammatory or autoimmune disease
abnormal karyotype;
polycystic ovarian syndrome,
endometriosis stage III/IV;
history of being a 'poor responder',
defined as >20 days of gonadotrophin in a previous stimulation cycle, or any previous cancellation of a stimulation cycle due to limited follicular response, or development of less than 4 follicles 15 mm in a previous stimulation cycle; history of recurrent miscarriage; severe OHSS in a previous stimula- tion cycle or any contraindication for the use of gonadotrophins.