Clinical and Magnetic Resonance Imaging Evaluation of Micro Fragmented Adipose Tissue Injection Combined With Bone Marrow Stem Cells on Healing of Temporomandibular Joint Internal Disc Derangement Without Reduction

Mohamed Talaat Abbas Hassan

Status: Not yet enrolling

Conditions: Temporomandibular Joint Disorders

Treatments: Procedure: Bone Marrow stem cells aspirate; Procedure: Micro fragmented adipose tissue mixed with bone marrow stem cells

Study type: Interventional

Funder types: Other

Identifiers

NCT05815771

Stem cells injection of TMJ

Details and patient eligibility

About

Arthrocentesis of TMJ then injection of micro fragmented adipose tissue mixed with bone marrow aspirate on healing of TMJ internal disc derangement without reduction.

Full description

Arthrocentesis of TMJ then injection of intra and periarticular of 2 mm of micro fragmented adipose tissue mixed with Bone marrow aspirate extracted from 20 mm of bone marrow using gradient separation method in one group and use of Bone marrow aspirate injection only in another group and injection of intra and periarticular of 2 mm hyaluronic acid gel in control group on healing of TMJ internal disc derangement without reduction.

Enrollment: 24 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with TMDs not previously surgically treated.
• Patients with TMJ osteoarthritis assessed by clinical examination and magnetic resonance imaging.

Exclusion criteria

• Patients refuse to be enrolled in this study.
• Patients with uncontrolled systemic disease.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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24 participants in 3 patient groups, including a placebo group

Micro fragmented adipose tissue

Active Comparator group

Description:

Micro fragmented adipose tissue mixed with Bone marrow stem cells injection on healing of TMJ internal disc derangement without reduction

Treatment:

Procedure: Micro fragmented adipose tissue mixed with bone marrow stem cells

Procedure: Bone Marrow stem cells aspirate

Bone marrow stem cells aspiration

Active Comparator group

Description:

Bone marrow stem cells injection on healing of TMJ internal disc derangement without reduction

Treatment:

Procedure: Micro fragmented adipose tissue mixed with bone marrow stem cells

Procedure: Bone Marrow stem cells aspirate

hyaluronic acid gel injection

Placebo Comparator group

Description:

Intra and periarticular injection of 2 mm of hyaluronic acid gel on healing of TMJ internal disc derangement without reduction

Treatment:

Procedure: Micro fragmented adipose tissue mixed with bone marrow stem cells

Procedure: Bone Marrow stem cells aspirate