Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alone and Combined With Enamel Matrix Proteins and Ox-derived Bone Graft in the Treatment of Single Bone Defects Between Teeth.

Rungta College of Dental Sciences and Research

Status: Completed

Conditions: Periodontal Diseases; Periodontal Bone Loss

Treatments: Procedure: modified minimally invasive surgical technique plus emdogain and xenograft; Procedure: modified minimally invasive surgical technique plus emdogain; Procedure: modified minimally invasive surgical technique

Study type: Interventional

Funder types: Other

Identifiers

NCT07310732

RCDSR/IEC/MDS/2021/b-11

Details and patient eligibility

About

This study was performed to investigate the adjunctive clinical benefit of the application of enamel matric derivatives and xenograft with the modified minimally invasive surgical technique in the treatment of isolated intrabony defects in periodontally compromised subjects.

Enrollment: 45 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• at least one site associated with an intrabony defect of ≥3 mm involving predominantly the interdental space of the tooth
• patients with optimal compliance

Exclusion criteria

• Patients with uncontrolled or poorly controlled diabetes
• history of long-term use of medications
• allergic to medications
• pregnant or lactating women
• smokers/users of other tobacco products

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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45 participants in 3 patient groups, including a placebo group

modified minimally invasive surgical technique

Placebo Comparator group

Treatment:

Procedure: modified minimally invasive surgical technique

modified minimally invasive surgical technique with emdogain

Active Comparator group

Treatment:

Procedure: modified minimally invasive surgical technique plus emdogain

modified minimally invasive surgical technique with emdogain and xenograft

Experimental group

Treatment:

Procedure: modified minimally invasive surgical technique plus emdogain and xenograft