Clinical and Radiographic Assessment of Nano-Bioactive Glass Combined With I-PRF Scaffold in Vital Pulp Treatments in Mandibular Molars With Closed Apices

Cairo University (CU)

Status: Enrolling

Conditions: Vital Pulp Treatment in Mature Permanent Teeth With Irreversible Pulpitis

Treatments: Procedure: Total pulpotomy with I-prf mixed with Nano-bioactive glass

Study type: Interventional

Funder types: Other

Identifiers

NCT05876520

ENDO-3-7-2

Details and patient eligibility

About

Clinical, Radiographic and pain assessment of Vital pulp treatment in patients suffering from irreversible pulpitis in mature permanent molars. Total pulpotomy is investigated using I-prf only vs I-prf mixed with Nano-bioactive glass.

Enrollment: 28 estimated patients

Sex: All

Ages: 14 to 32 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients suffering from Symptomatic irreversible pulpitis in mature mandibular molars only will be involved.
• Tooth should give positive response to cold test
• Haemostasias should be achieved after total pulpotomy
• The tooth is restorable and free from advanced periodontal disease, cracks and splits.
• Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
• Patients who will agree to the consent and will commit to follow-up period.
• Patients with mature root apices
• Patients with no internal or external resorption and no periapical lesions
• Soft tissues around the tooth are normal with no swelling or sinus tract.

Exclusion criteria

• Patients with immature roots.
• Haemostasias after 10 minutes can not be controlled after total pulpotomy
• Patients with any systemic disease that may affect normal healing.
• Patients with periapical lesions or infections.
• Pregnant females.
• Patients who could/would not participate in a 6 months follow-up.
• Patients with fistula or swelling
• Patients with necrotic pulp.
• Patients with old age.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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28 participants in 1 patient group

Total pulpotomy with I-PRF only

Other group

Description:

Total pulpotomy is done in mature permanent molars followed by I-prf application. Topped with BC putty for coronal seal, RMGI and restored with composite as final restoration

Treatment:

Procedure: Total pulpotomy with I-prf mixed with Nano-bioactive glass