Clinical and Radiological Effect Of Platelet Rich Fibrin on the Healing of Periodontal Intrabony Periodontal Defects

Baskent University

Status

Completed

Conditions

Chronic Periodontitis

Intrabony Periodontal Defect

Treatments

Other: Anorganic Bovine Bone Mineral and Platelet Rich Fibrin (PRF)

Other: Anorganic Bovine Bone Mineral (ABBM)

Study type

Interventional

Funder types

Other

Identifiers

NCT02836314

03/10-12

Details and patient eligibility

About

The aim of this split mouth, single-center, controlled study is to compare the healing of intrabony defects treated with a combination of Anorganic Bovine Bone Mineral (ABBM)/Platelet Rich Fibrin (PRF) or Anorganic Bovine Bone Mineral alone. The hypothesis being tested in the study was that PRF would augment the regenerative effects of ABBM in human intrabony defects.

Full description

Anorganic bovine bone mineral (ABBM) is extensively used in the treatment of intrabony defects. Platelet rich fibrin (PRF) is a new generation platelet concentrate with a simplified technique. Although there are some studies on the use of PRF in the treatment of intrabony defects, to date none of them evaluate its additive effects with ABBM. Therefore, a randomized, split mouth clinical trial was conducted to compare the healing of intrabony defects treated with a PRF/ABBM combination and to those obtained with ABBM alone. Using a split mouth design, 15 paired intrabony defects were randomly treated with either ABBM alone (control group) or with ABBM- PRF combination (test group). The following clinical parameters and radiographic measurements were recorded at baseline and six months postoperatively: plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), clinical attachment level (CAL), vertical bone loss, the depth of the defect and defect angle

Enrollment

15 patients

Sex

Ages

38 to 61 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

no systemic diseases;
a good level of oral hygiene (OH) (plaque index<0.15);
presence of two paired two-wall or three-wall intrabony defects with probing depth ≥6mm and an intrabony component ≥3mm as detected on radiographs; -no intrabony defects extending into the furcation area;
tooth mobility ≤1;
tooth and adjoining teeth testing vital and without symptoms or signs of endodontic involvement;
tooth and adjoining teeth free of caries or inadequate restorations.

Exclusion criteria

patients with compromised immune systems;
pregnant and/or lactating women;
patients taking any drug known to affect the periodontal status or affect the coagulation system
smokers.