Clinical and Radiological Evaluation of Meniscal Healing After Percutaneous Intra-meniscal Injection of Platelet-rich Plasma (PRP) (COMPARE)

Civil Hospices of Lyon

Status: Completed

Conditions: Meniscus Lesion

Treatments: Procedure: Intra-meniscal injection of platelet-rich plasma

Study type: Observational

Funder types: Other

Identifiers

NCT03966638

CRC_GHN_2019_006

Details and patient eligibility

About

Meniscal lesions are a common pathology among athletes, and have an impact on the daily or sporting practice of patients. The consequences of surgical treatment are sometimes heavy.

Platelet-rich-plasma (PRP) has been shown to be effective in healing tendon and ligament lesions.

PRP has been injected under ultrasound in tendons or intra-articularly for several years.

This technique of meniscal percutaneous injection of PRP is now carried out for more than 2 years in our hospital, with satisfactory preliminary results, without any complication.

All patients in our study received an intra-meniscal injection of PRP, under echographic control. They were evaluated clinically and by Magnetic Resonance Imaging (MRI) before and at 6 months of the injection.

The aim of the study is to evaluate the efficacy of intra-meniscal injection of PRP on the symptomatology of the patients (pain, sport activities and daily life) at 6 months post-treatment.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• isolated symptomatic meniscal lesion
• lesion confirmed by MRI
• grade II or III lesion touching the peripheral involvement of the middle segment,
• lesion treated by percutaneous intra meniscal PRP's injection
• IKDC score measured before injection and 6 months post-injection

Exclusion criteria

• other painful etiology of the knee
• emergency surgical management (luxation, bucket handle) or not (indication validated by the surgeon, meniscectomy or meniscal suture)
• impossibility to perform the procedure (non visible lesion, morphology of the patient, cutaneous infection, coagulation treatment in progress)

Trial design

40 participants in 1 patient group

Patients receiving platelet rich plasma

Description:

The group is composed of patients receiving an intra-meniscal injection of platelet-rich plasma, under echographic control, for isolated meniscal lesion.

Treatment:

Procedure: Intra-meniscal injection of platelet-rich plasma