Clinical and Radiological Outcomes of Subchondroplasty in the Treatment of Bone Marrow Edema of the Knee

University of Milan

Status

Completed

Conditions

Bone Marrow Edema

Treatments

Procedure: subchondroplasty

Study type

Interventional

Funder types

Other

Identifiers

NCT04905394

SubCond

Details and patient eligibility

About

Bone marrow lesions (BMLs) of the knee are common subchondral defects, often associated with pain and functional limitation. Subchondroplasty is a percutaneous procedure in which calcium phosphate is injected inside BML areas, ensuring stability and promoting the deposition of new bone. Primary outcome of this study was to obtain a reduction of the Numeric Rating Scale score of 4 points or more at 6 months follow-up in more than 75% of patients. The secondary outcome was to evaluate the osteoarthritic and bone marrow structure evolution in the months after the procedure.

Enrollment

50 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Atraumatic knee pain for at least 3 months;
Failure of conservative treatment (including NSAIDs, physical therapy, intra- articular injection with steroids or hyaluronic acid and bisphosphonates);
Mild to moderate osteoarthritis (Kellgren-Lawrence18 grade ≤ 3)
BML on a loading area at MRI imaging (femoral condyles and/or tibial plateau)

Exclusion criteria