Clinical Application of Carbon Nanoparticles in Lymph Node Tracing and Surgery Guiding of Colorectal Cancer (CNP-CRC)

Zhejiang University

Status: Completed

Conditions: Colorectal Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT06783985

SirRRSH-CNP-CRC

Details and patient eligibility

About

This trial aims to clarify the relationship between carbon nanoparticles labeled lymph nodes and lymph node metastasis in different lymph node regions of colorectal cancer, and to clarify the application value of carbon nanoparticles in lymph node dissection in colorectal cancer surgery.

Enrollment: 146 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. a diagnosis of colorectal cancer;
2. endoscopic injection of CNP suspension preoperatively
3. planned radical resection of colorectal cancer
4. older than 18 years of age

Exclusion criteria

(a) emergency surgery;

Trial design

146 participants in 1 patient group

CNP group

Description:

Every patient received endoscopic injection of 0.5 ml CNP suspension (Chongqing LUMMY Pharmaceutical Co., Chongqing, China) into submucosal layer at one point, at the lower margin of the tumor. All patients subsequently underwent laparoscopic or robotic radical resection with D3 LN dissection. Tumor tissue and LNs s were isolated from surgical specimen by the same pathologist. LNs dissection and harvest were on the basis of the Japanese classification of colorectal carcinoma.