Clinical Application of Dual Sentinel Lymph Node Staining Method in Breast Cancer

National Cancer Center (NCC)

Status

Completed

Conditions

Breast Cancer

Treatments

Procedure: sentinel lymph node biopsy(SLNB)

Study type

Observational

Funder types

Other

Identifiers

NCT02168452

NCC-1410201-1

Details and patient eligibility

About

This study aimed to evaluate the feasibility of dual sentinel node staining method using mixture of indocyanine green(ICG) and radioisotope (RI) in breast cancer patients who receive neoadjuvant chemotherapy.

Over the past few years, several studies have found using methylene blue, isosulfan blue, indocyanine green or radioisotope alone by detection method had several disadvantages.

In this study we expects using mixture of indocyanine green (ICG) with radioisotope (RI) has potential to improve sentinel lymph node (SLN) mapping in breast cancer patients who receive neoadjuvant chemotherapy.

Full description

5 patients who receive neoadjuvant chemotherapy with cN1-cN2 or cT2 on TNM staging
sentinel lymph node biopsy(SLNB) by sentinel lymph node staining method using mixture of indocyanine green (ICG) with radioisotope (RI).
indocyanine green (ICG) penetrates human tissue to depths of several millimeters to 2cm, and the fluorescence can be detected percutaneously in real time.
using RI only has several disadvantages such as invisibility,interference. RI only detect sound or confirm numerical value through gamma probe.
ICG can be visualized with a fluorescence imaging system
confirm Identification rate of sentinal lymph node biopsy, and duration of sentinel lymph node biopsy

Enrollment

5 patients

Sex

Female

Ages

20 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria