Clinical Application of Novel Panels for Early Precision Diagnosis and Relapse Prediction in High-risk Leukemia

Southeast University

Status: Completed

Conditions: Leukemia, Acute

Treatments: Diagnostic Test: High-risk subtype detection panels

Study type: Observational

Funder types: Other

Identifiers

NCT03297476

ZDYYGZ201708

Details and patient eligibility

About

Based on the investigator's previous data on risk classification for acute leukemia,the investigators will design a set of panels to detect the gene expression and genomic variants (SNPs, mutation, insertion, deletion and fusion genes, etc), and identify the high-risk subtypes of acute leukemia, such as Ph-like acute lymphoblastic leukemia. Furthermore, the target therapy (Tyrosine Kinase Inhibitors,et.al) will be used to treat the identified patients. In addition, more sensitive minimal residual disease (MRD) detection technology will be designed and used to detect the MRD in patients to early predict the disease relapse.

Full description

patient eligibility criteria: newly diagnosed acute leukemia patients with clinical high-risk markers, reflactory and relapsed patients.

Enrollment: 100 patients

Sex: All

Ages: 14 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Newly diagnostic acute lymphoblastic leukemia Be willing to start treatment

Exclusion criteria

• chronic leukemia

Trial design

100 participants in 2 patient groups

high-risk group

Description:

Selected by "High-risk subtype detection panels"

Treatment:

Diagnostic Test: High-risk subtype detection panels

non high-risk group

Description:

Selected by "High-risk subtype detection panels"

Treatment:

Diagnostic Test: High-risk subtype detection panels