Clinical Application of Quantitative Ultrasonographic Analysis in Early Kidney Injury

Soochow University

Status: Enrolling

Conditions: Patient Admitted to Hospital With Acute Kidney Injury Due to Sepsis

Treatments: Diagnostic Test: Ultrasound contrast agent (Sonovue)

Study type: Observational

Funder types: Other

Identifiers

NCT05662774

JD-HG-2021-40

Details and patient eligibility

About

The purpose of this study was to quantify overall blood flow and renal cortical perfusion in patients with septic acute kidney injury (AKI) using ultrasound (US) Doppler and contrast-enhanced ultrasound (CEUS).

Full description

Kidney ultrasound is the most widely used imaging modality in initial AKI workup as it is widely available and free of complications. It is clinically feasible to use US Doppler and contrast-enhanced US (CEUS) to detect macroscopic and microscopic changes in renal blood flow, and also cardiac output alterations.The aim was to analyze changes in US Doppler and CEUS quantitative parameters in patients with septic AKI to explore perfusion within the renal parenchyma, and also measure global renal blood flow and cardiac output.

Enrollment: 100 estimated patients

Sex: All

Ages: 19 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Meets the AKI diagnostic criteria of the Kidney Disease: Improving Global Outcomes (KDIGO)
2. Meets Sepsis 3.0 diagnostic criteria for sepsis: infection + SOFA ≥ 2

Exclusion criteria

1. Urinary tract obstruction, hydronephrosis, etc.
2. Left ventricular ejection fraction <30% (measured by transthoracic echocardiography), systolic pulmonary artery pressure >90 mmHg (measured by transthoracic echocardiography)
3. Allergy or adverse reaction to contrast media