Clinical Applications of Domperidone in Patients With Delayed Gastric Emptying

Mt. Sinai Medical Center, Miami

Status: Completed

Conditions: Digestive System Disease

Treatments: Other: Domperidone

Study type: Interventional

Funder types: Other

Identifiers

NCT01844622

07-39-H-08

Details and patient eligibility

About

The purpose of the study is to treat patients with on-going slow stomach emptying(gastroesophageal reflux disease), who have failed to respond to standard therapy

Full description

This is a study on the effectiveness of domperidone, which increases movement through the digestive system for relief of symptoms, in patients who have delayed gastric solid-phase emptying

Enrollment: 37 patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Persistent esophagitis
• Heartburn
• Nausea
• Vomiting
• Severe dyspepsia
• Severe chronic constipation

Exclusion criteria

• History of, or current arrhythmias including ventricular tachycardia, - Ventricular fibrillation and Torsade des Pointes.

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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37 participants in 1 patient group

Domperidone

Other group

Description:

Domperidone will be given at 10 mg before each meal and at bedtime. At completion of the study, patients will receive standard medical therapy

Treatment:

Other: Domperidone