Clinical Characteristics and Molecular Mechanism of Patients With Obstructive Sleep Apnea

Capital Medical University

Status: Enrolling

Conditions: Obstructive Sleep Apnea

Study type: Observational

Funder types: Other

Identifiers

NCT07277608

2023-ke-450

Details and patient eligibility

About

To clarify the clinical features of patients with obstructive sleep apnea; To construct a multi-omics database of patients with obstructive sleep apnea, and compare the effects of different degrees of sleep apnea on prognosis, immunity, and metabolism. The medium and long-term prognosis, complications, comorbidities, risk factors, and immune and metabolic dynamics of patients with sleep apnea after treatment were studied. To elucidate the biomarkers and therapeutic targets associated with obstructive sleep apnea.

Enrollment: 500 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with suspected obstructive sleep apnea (OSA) admitted to the sleep center of the respiratory Department of Beijing Chaoyang Hospital, Capital Medical University.
• Volunteer to participate in the study and sign an informed consent, and can complete at least 1 year of follow-up.

Exclusion criteria

• Patients with obstructive sleep apnea who have been treated with impermanent positive pressure ventilation;
• Pregnant or lactating women;
• Patients with severe respiratory failure requiring mechanical ventilation;
• Patients with severe heart, lung, liver, kidney, and central nervous system damage;
• Refuse to participate in follow-up visits and/or take biological samples.

Trial design

500 participants in 3 patient groups

Severe OSA

Non-severe OSA

Healthy controls