Clinical Characteristics of Patients With Sleep Apnea in Korea

Seoul National University

Status: Enrolling

Conditions: Sleep Apnea Syndromes

Study type: Observational

Funder types: Other

Identifiers

NCT04186078

19071511050

Details and patient eligibility

About

Sleep-disordered breathing including obstructive sleep apnea (OSA) is an extremely common medical disorder associated with important morbidity. The purpose of this study is to understand the clinical features and course of patients with sleep apnea in Korea. Participants who are suspected of sleep apnea due to symptoms such as snoring, witnessed apneas, waking up with a choking sensation, excessive sleepiness, non-restorative sleep, difficulty initiating or maintaining sleep, fatigue or tiredness, and morning headache will be prospectively recruited at the outpatient clinic of Seoul National University Hospital. After polysomnography (PSG) or respiratory polygraphy, patients with sleep apnea including OSA and central sleep apnea (CSA) will be followed regularly. Participants not having sleep apnea (apnea-hypopnea index < 5/hour) will only have a baseline visit. For only participants with the informed consent of donating blood, their blood samples will be collected and stored in the Seoul National University Hospital-Human Biobank (SNUH-HUB).

Enrollment: 1,000 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants who are suspected of sleep apnea due to symptoms such as snoring, witnessed apneas, waking up with a choking sensation, excessive sleepiness, non-restorative sleep, difficulty initiating or maintaining sleep, fatigue or tiredness, and morning headache

Exclusion criteria

• None

Trial design

1,000 participants in 3 patient groups

obstructive sleep apnea (OSA)

Description:

5 or more predominantly obstructive respiratory events \[obstructive and mixed apneas, hypopneas or respiratory effort-related arousals (RERAs)\] per hour of sleep during a PSG or per hour of monitoring (respiratory polygraphy)

central sleep apnea (CSA)

Description:

PSG shows all of the following: 1. 5 or more central apneas and/or central hypopneas per hour of sleep. 2. The number of central and/or central hypopneas is \> 50% of the total number of apneas and hypopneas.

control

Description:

apnea-hypopnea index \< 5 per hour of sleep during a PSG or per hour of monitoring (respiratory polygraphy)