Clinical Comparative Study of Systematic Therapy Combined With MWA and Systematic Therapy for Pancreatic Cancer

Chinese PLA General Hospital (301 Hospital)

Status: Not yet enrolling

Conditions: Ablation; Pancreatic Neoplasms

Treatments: Procedure: Systematic Therapy Combined With Microwave Ablation

Study type: Observational

Funder types: Other

Identifiers

NCT06231160

82171941

Details and patient eligibility

About

Pancreatic carcinoma (PC) is the deadliest malignant tumors worldwide. Surgical resection is one of the most effective methods for the treatment of PC, but the resectable rate is less than 20% among the patients with PCs, and the recurrent and metastatic rate is more than 80% in two years after resection. Ablation has been confirmed one of the most effective methods for solid tumors by recent twenty years and proven to be a radical treatment similar to the surgical resection for the clinical applications of hepatic and renal tumors at early clinical staging in the internationally guidelines. The purpose is to explore the efficacy and safety of microwave ablation in the treatment of pancreatic cancer in combination with systematic therapy.

Full description

Pancreatic carcinoma (PC) is the deadliest malignant tumors worldwide. Surgical resection is one of the most effective methods for the treatment of PC, but the resectable rate is less than 20% among the patients with PCs, and the recurrent and metastatic rate is more than 80% in two years after resection. Furthermore, it is difficult to achieve tumoral complete responses by traditional therapies including chemotherapy, radiotherapy and transarterial embolization. Ablation has been confirmed one of the most effective methods for solid tumors by recent twenty years and proven to be a radical treatment similar to the surgical resection for the clinical applications of hepatic and renal tumors at early clinical staging in the internationally guidelines. However, the published clinical practices on the thermal ablation of PCs with large-scale cases are rare. One of the most important reasons for this originates from the extreme complexity and difficult regulation of the temperature distribution in tumors during thermal ablation because of the own characteristics of PCs, including highly invasive growth without tumoral capsules, high proportion of the interstitial fiber tissue, and the unusual blood perfusion because of extremely chaotic microvascular structures. The purpose is to explore the efficacy and safety of microwave ablation in the treatment of pancreatic cancer in combination with systematic therapy.

Enrollment: 185 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Inoperable pancreatic cancer
• Age from 18 to 80
• PS score from 0 to 3
• Clear pathological diagnosis

Exclusion criteria

• Severe coagulation dysfunction
• Individuals with severe heart, lung, liver, and kidney dysfunction
• Individuals with acute or active infectious lesions in any part of the body
• Researchers believe that there are any other factors that are not suitable for inclusion or that affect the participation of participants in the study
• Psychological health issues that hinder this experiment

Trial design

185 participants in 2 patient groups

Systematic Therapy Combined With Microwave Ablation

Description:

Perform microwave ablation for patients with pancreatic cancer, and then conduct chemotherapy according to the guidelines two to three weeks later

Treatment:

Procedure: Systematic Therapy Combined With Microwave Ablation

Systematic Therapy

Description:

Using the same chemotherapy method as the experimental group