Clinical Effectiveness of Episodic Use of Bioactive Silica Based Versus in Management of Dentin Hypersensitivity (A 6m Randomized Clinical Trial)

Rawda Hesham Abd ElAziz

Status: Not yet enrolling

Conditions: Dentin Hypersensitivity

Treatments: Procedure: episodic use of the desensitizing toothpaste; Procedure: continuous use of the conventional desensitizing toothpaste

Study type: Interventional

Funder types: Other

Identifiers

NCT07120139

CONS2R

Details and patient eligibility

About

The aim of the study to compare the clinical effectiveness of Episodic use of Bioactive Silica Based versus continuous use of fluoride based desensitizing toothpastes in management of dentin hypersensitivity (DH) of adult patients over 6m follow up and evaluating patient satisfaction regarding the treatment provided. Episodic use will be tested as it reflects the effectiveness in a clinical scenario regarding patient compliance and adherence to the treatment where some of the Egyptian patients stop the treatment once improvement occurs due to financial constraints

Enrollment: 50 estimated patients

Sex: All

Ages: 22 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients with DH, VAS ≥ 3 and Schiff sensitivity score needed to be ≥2, indicating that application of a jet of air makes the patient respond and move or requests discontinuation of the stimuli application.

• Teeth with DH related to Non- carious Cervical lesions (abrasion, abfracture, erosion).

• Teeth with gingival recession and exposed root dentin.

Exclusion criteria

• Patients with known allergies or adverse reactions to any ingredient of the tested materials.

Systematic disease and/ or physical disabilities that may affect participation. • Patients who did any periodontal surgeries within the previous 3 months.

• Patients with orthodontic appliances, or restorative work that might interfere with evaluation.

• Patient who frequently use analgesics or any drugs that could affect the pain level.

• Home or in-office bleaching and/ or in office fluoride application for 6 months before beginning of treatment.

• Pregnant females with frequent vomiting attacks.

• Smokers.

• Systemic conditions that cause or predispose patients to develop dentin hypersensitivity (for example, gastroesophageal reflux disease, GERD).

• Excessive dietary or environmental exposure to acids.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 4 patient groups

Group 1 Episodic use of Refix booster Bioactive Silica with calcium booster toothpaste

Experimental group

Treatment:

Procedure: episodic use of the desensitizing toothpaste

Group 2: Episodic use of Regenerador Sentitive: Bioactive Silica Based toothpaste,

Experimental group

Treatment:

Procedure: episodic use of the desensitizing toothpaste

Group 3: Episodic use of (Sensodyne Rapid action) Fluoride containing desensitizing Toothpaste,

Experimental group

Treatment:

Procedure: episodic use of the desensitizing toothpaste

Group 4: Continuous use of (Sensodyne Rapid action) Fluoride containing desensitizing Toothpaste

Active Comparator group

Treatment:

Procedure: continuous use of the conventional desensitizing toothpaste