Clinical Effectiveness of Polymethoxy Flavones Solid Dispersion as a Dressing Material for Palatal Grafts Donor Sites (RCT)

Assiut University

Status: Not yet enrolling

Conditions: Gingival Recession; Soft Tissue Infections

Treatments: Other: Placebo; Drug: hydroxylate flavones solid dispersion application

Study type: Interventional

Funder types: Other

Identifiers

NCT05814003

HW37

Details and patient eligibility

About

Free gingival grafting surgeries require palatal grafts harvesting from the patient own palates . The donor sites pain , infection and retarded healing by secondary intension are the complication .

Full description

After the preparation and characterization of the solid dispersion of hydroxylated methoxy flavones, free gingival grafting surgeries require palatal grafts harvesting from the patient own palates . The donor sites pain , infection and retarded healing by secondary intension are the complications ; the aim of the study is to assess the analgesic , anti inflammatory effects of hydroxylated methoxy flavones.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• insufficient zone of keratinized gingiva recession of the gingiva non smokers free from systemic disorders

Exclusion criteria

• smokers insufficient palatal donor sits un realistic expectations

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 3 patient groups, including a placebo group

hydroxylate flavones

Experimental group

Description:

flavonoids mainly derived from citrus peel and have numerous strong biological activities, including anti-inflammatory , antioxidant , antimicrobial , and anticancer

Treatment:

Drug: hydroxylate flavones solid dispersion application

Other: Placebo

alveogyl

Active Comparator group

Description:

ALVOGYL is a brown fibrous paste which contains per 100 g the following active ingredients : 25.70 g of butamben, 15.80 g of iodoform and 13.70 g of eugenol.

Treatment:

Drug: hydroxylate flavones solid dispersion application

Other: Placebo

stent

Placebo Comparator group

Description:

acrylic resin material used to cover denuded soft tissues

Treatment:

Drug: hydroxylate flavones solid dispersion application