Clinical Effects of Soluble Dietary Fiber Supplementation

Nanjing PLA General Hospital

Status and phase: Completed; Phase 3

Conditions: Hypomotility; Constipation

Treatments: Drug: Pectin

Study type: Interventional

Funder types: Other

Identifiers

NCT02194972

2011NLY42

Details and patient eligibility

About

The purpose of this study is to investigate the effect of pectin, a kind of soluble dietary fiber, on colonic transit time, clinical symptoms and the gut microbiota in adults with slow-transit constipation.

Full description

Patients were randomized to receive either pectin or placebo. Treatment consisted of 4 weeks supplementation with pectin (fiber group) or placebo. We evaluated the colonic transit time, constipation symptoms and fecal bacterial population in two groups.

Enrollment: 80 patients

Sex: All

Ages: 18 to 78 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients(age≧18y)
• Admitted for slow-transit constipation were considered eligible

Exclusion criteria

• Mental disorders
• Cancer
• Inflammatory bowel disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 2 patient groups

soluble dietary fiber

Experimental group

Description:

pectin, a kind of soluble dietary fiber

Treatment:

Drug: Pectin

Placebo

No Intervention group

Description:

Placebo