Clinical Efficacy and Safety of Metformin Versus Apple Cider Vinegar (ACV) in Prediabetics (BUHSCK)

Bahria University

Status: Completed

Conditions: PreDiabetes

Treatments: Dietary Supplement: Apple cider vinegar; Drug: Metformin Hydrochloride (HCL)

Study type: Interventional

Funder types: Other

Identifiers

NCT05759442

ERC 123/2022

Details and patient eligibility

About

The goal of this clinical trial is to compare efficacy and safety of metformin versus apple cider vinegar in prediabetics . The main question[s] it aims to answer are:

• Efficacy of metformin versus apple cider vinegar in prediabetics
• Safety of metformin versus apple cider vinegar in prediabetics

Researchers will compare group of prediabetics taking metformin with group of prediabetics taking apple cider vinegar to see if there is difference in safety and efficacy..

Enrollment: 46 patients

Sex: All

Ages: 17 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Males and Female
• 17-40 years age
• Body Mass index (BMI) overweight and obese
• FBS (100-125 mg/dl)
• HBA1c 5.7% to 6.4%

Exclusion criteria

• Concomitant medical problems as established diabetes, hepatic or renal insufficiencies etc.
• Known allergy or intolerance to metformin or apple cider vinegar

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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46 participants in 2 patient groups

Metformin

Active Comparator group

Description:

Tablet Metformin HCl 500 mg per oral twice daily for 12 weeks

Treatment:

Drug: Metformin Hydrochloride (HCL)

Apple cider vinegar

Active Comparator group

Description:

Apple Cider Vinegar 15ml per day diluted in 200 ml of water for 12 weeks

Treatment:

Dietary Supplement: Apple cider vinegar