Clinical Efficacy of a Chlorhexidine-based Mouth-rinse Containing Citrus Aurantium Amara (CUR_01)

University of Roma La Sapienza

Status

Not yet enrolling

Conditions

Wound Healing

Treatments

Other: CHX 0.09% + Citrox + HA

Drug: CHX 0.12%

Study type

Interventional

Funder types

Other

Identifiers

NCT06738342

0460/2022

Details and patient eligibility

About

The primary objective of the study is the evaluation of efficacy of a mouthwash cointaining Chlorexidine (CHX) 0.09% + HA + Citrox (test group) on the quality of wound healing and the presence plaque formation and gingival inflammation in the post-surgical phase. Futhermore stains, discolorations and adverse effects will be eventually recorded. Control group will be represented by the use of a CHX 0.12% mouthwash.

Enrollment

32 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

More than 20 natural teeth excluding the third molars
Clinical indication for a surgical intervention for the treatment of at least one residual pocket after non-surgical therapy (pocket depth (PD) ≥5mm)
Have a full mouth plaque score (FMPS) <15% before surgery;
Have a full mouth bleeding score (FMBS) <15% before surgery;
Ability and willingness to give written informed consent;
Written agreement to participate in the trial.

Exclusion criteria

Use of medications, such as anti-platelet or anti-coagulant agents, any other concomitant systemic disorder, cardiovascular and diabetes diseases, allergic, infectious diseases and medications affecting periodontal inflammation
Pregnancy or breastfeeding;
Use of medication affecting the healing process;
Assumption of systemic or local antibiotics in the 4 weeks before trial beginning;
Conditions of the teeth or of the site that contraindicate the surgery (severe mobility, fractures, untreated endodontic lesions, incongruous restorations);
Patients with previous periodontal treatment or who were undergoing a course of dental or orthodontic treatment will be also excluded.
Tobacco use (10 or more cigarettes per day)
Inability to comply with protocol
Uncooperative patient