Clinical Efficacy of Amoxicillin Given Twice or Three Times a Day Among Children With Non-severe Pneumonia (PNEUMOPACEf)

Federal University of Bahia

Status and phase

Completed

Phase 4

Conditions

Community-acquired Pneumonia

Treatments

Drug: Amoxicillin

Study type

Interventional

Funder types

Other

Identifiers

NCT01200706

APR0127/2006

Details and patient eligibility

About

The purpose of the study is to compare the clinical efficacy of amoxicillin given twice or three times a day to children with non-severe community-acquired pneumonia.

Enrollment

820 patients

Sex

All

Ages

2 to 59 months old

Volunteers

No Healthy Volunteers

Inclusion criteria

Children aged between 2 and 59 months
Report of respiratory complaints
Presence of pulmonary infiltrate on chest x-ray taken on admission and read by the pediatrician on duty

Exclusion criteria

lower chest indrawing
danger signs (inability to drink, convulsions, somnolence, central cyanosis, grunting in a calm child)
diagnosed underlying chronic diseases (anatomic abnormalities of the respiratory tract, chronic pulmonary illness besides asthma, immunological defects, progressing neurological disorders, psychomotor retardation, heart disease with clinical repercussion, hemoglobinopathy, liver or kidney disease)
severe malnutrition
other concurrent infection
hospitalization during the previous 7 days
amoxicillin or similar antibiotic use during the last 48 hours
allergy to amoxicillin
history of aspiration