Clinical Efficacy of Bovine Freeze-dried Amniotic Membrane on Wound Healing in Laser Treatment

Seoul National University

Status: Completed

Conditions: Biological Dressings

Treatments: Procedure: laser treatments; Device: hydrocolloid application; Other: amniotic membrane application

Study type: Interventional

Funder types: Other

Identifiers

NCT01895374

2012-0320

Details and patient eligibility

About

Bovine amniotic membrane may show better efficacy than hydrocolloid dressing.

Full description

Bovine amniotic membrane as a biological dressing can be applicable to wound after laser treatments. Comparing with hydrocolloid dressing material, which is the most widely used after laser treatment now, amniotic membrane will show better efficacy. Thus, with amniotic membrane, epithelization time will shorten and redness which is usually left after laser will disappear quickly.

Enrollment: 51 patients

Sex: All

Ages: 19 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Skin lesions treatable by ablative lasers
• More than two skin lesions of similar size at the same area
• Available during the study period (2 weeks)

Exclusion criteria

• Taking steroid or nonsteroidal antiinflammatory drug, isotretinoin
• underlying diabetes mellitus, keloid or any malignancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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51 participants in 2 patient groups

amniotic membrane dressing

Experimental group

Description:

We compare the efficacy of amniotic membrane and hydrocolloid in same subjects to avoid confounders.

Treatment:

Other: amniotic membrane application

Procedure: laser treatments

Hydrocolloid dressing

Active Comparator group

Description:

Same subjects received amniotic membrane and hydrocolloid dressing at the same time in different wound.

Treatment:

Device: hydrocolloid application

Procedure: laser treatments