Clinical Efficacy of Combination Therapy Based on High-dose Biapenem in CRKP Infections

Zhejiang University

Status: Unknown

Conditions: High-dose Biapenem

Treatments: Drug: Biapenem

Study type: Observational

Funder types: Other

Identifiers

NCT04552444

SAHZU2017087

Details and patient eligibility

About

Carbapenem resistance is a high mortality rate of Klebsiella pneumoniae infection. It has been proved that high-dose carbapenem can reduce mortality and has a certain clinical effect. In this study, a high dose of biapenem was compared to determine whether it had a similar effect than meropenem.

Enrollment: 200 estimated patients

Sex: All

Ages: 14 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ICU hospitalized for more than 3 days;
• Biapenem used for more than 3 days

Exclusion criteria

• Patients who refuse to be included in the group or pregnant women or under the age of 14 or ICU hospitalized for less than 3 days

Trial design

200 participants in 2 patient groups

the death group

Description:

Through the corresponding treatment, the patients who died within 28 days

Treatment:

Drug: Biapenem

the survival group

Description:

Through the corresponding treatment, the patients who survived within 28 days

Treatment:

Drug: Biapenem