Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Knee Osteoarthritis

Kufa University

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Combination Product: Ginkgo biloba extract + standard treatment( paracetamol+Diclofenac100mg SR); Combination Product: placebo in addition to the standard treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT05398874

MEC-13

Details and patient eligibility

About

To assess the efficacy and safety of the Ginkgo biloba extract in patients with Knee OA.

Enrollment: 60 patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients 40-75 years old with knee OA.
• Grade II and Grade III according to the Kellgrenn-Lawrence (KL) grading system of radiographic OA.

Exclusion criteria

• Pregnancy, breastfeeding
• Liver or renal problems
• Patient taking any drug that might interact with Ginkgo extract (eg. warfarin, etc.)
• patient with cardiovascular or cerebral vascular disorders, uncontrolled diabetes, allergic to ginkgo, recent surgery or hospital admission, >75 years old.
• Allergic or contraindicated to using NSAIDs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

60 participants in 2 patient groups, including a placebo group

Ginkgo + standard

Active Comparator group

Description:

the patients received Ginkgo biloba extract in addition to standard treatment

Treatment:

Combination Product: Ginkgo biloba extract + standard treatment( paracetamol+Diclofenac100mg SR)

placebo + standard

Placebo Comparator group

Description:

the patients received a placebo in addition to the standard treatment

Treatment:

Combination Product: placebo in addition to the standard treatment