Clinical Efficacy of NST With Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grade B Periodontitis.

Cairo University (CU)

Status: Not yet enrolling

Conditions: Periodontitis, Adult

Treatments: Procedure: full mouth non-surgical scaling

Study type: Interventional

Funder types: Other

Identifiers

NCT07184268

892025

Details and patient eligibility

About

The aim of this clinical trial is to evaluate the effectiveness of local delivery ozonated olive gel versus curcumin gel as adjunct to scaling and root planing in the treatment of stage II grade B periodontitis in on both males and females in the age group between 18 and 50 years. outcome measures are Clinical attachment level (CAL), plaque index (PI), gingival index (GI).

Full description

Periodontitis is an advanced periodontal disease with a distinctive clinical signs and symptoms as rapid attachment loss and bone destruction

The primary treatment approach for periodontitis is mechanical plaque removal through debridement, particularly scaling and root planing (SRP) using hand or ultrasonic instruments.

curcumin gel is an adjunct to non-surgical periodontal therapy is a highly potent local antioxidant and anti-inflammatory agent. While ozone has a potent antimicrobial and anti-inflammatory effects it also can be incorporated into a lipid carrier such as olive oil. Ozone's stability and ease of application are markedly enhanced. Ozonized olive oil can be formulated into a gel with ideal rheological properties for injection into periodontal pockets.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients diagnosed with stage II periodontitis defined by having interdental CAL 3-4 mm and presence of pocket depth (PD) ≤ 5 mm, and grade B periodontitis characterized by a moderate rate of disease progression.
2. Patients agree to a 3-month follow-up period and provide an informed consent.

Exclusion criteria

1. Presence of prosthetic crowns, overhanging restorations and orthodontic treatment.
2. Teeth with both endo-perio lesions.
3. Antibiotics therapy that has an impact on the clinical signs and symptoms of periodontitis in the previous 3 months.
4. Anti-inflammatory drugs in the previous 1 month.

6. History of systemic disease, allergy, cardiovascular diseases, diabetes mellitus, hypertension, bleeding disorders, hyperparathyroidism, and compromised medical conditions, pregnant and lactating females.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

curcumin gel

Active Comparator group

Description:

The curcumin gel will be gently deposited into the periodontal pockets to ensure adequate subgingival delivery.

Treatment:

Procedure: full mouth non-surgical scaling

ozonated olive gel.

Active Comparator group

Description:

patients will receive subgingival application of ozonated olive oil in the periodontal pocket

Treatment:

Procedure: full mouth non-surgical scaling