Clinical Efficacy of Roxithromycin in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome

The Catholic University of Korea

Status: Completed

Conditions: Chronic Prostatitis; Chronic Pelvic Pain Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT01843946

Rulid-2011

Details and patient eligibility

About

Roxithromycin is effective in the treatment of intracellular organisms, including chlamydia and mycoplasma, and exhibits anti-inflammatory and immunomodulatory effects on respiratory diseases. To explore the potential therapeutic benefit of roxithromycin in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), this study compared the effect of roxithromycin with ciprofloxacin and aceclofenac.

Full description

A total of 75 patients with CP/CPPS were randomized to three groups in open-label: group 1, ciprofloxacin; group 2, aceclofenac; and group 3, roxithromycin. The patients were treated for 4 weeks and were subsequently followed for 12 weeks. Changes from baseline in the total and domain scores of the NIH Chronic Prostatitis Symptom Index (NIH-CPSI) were evaluated.

Enrollment: 75 patients

Sex: Male

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of category IIIa of IIIb chronic prostatitis
• NIH-CPSI (National Institute of Health Chronic Prostatitis Symptom Index) score ≥ 15

Exclusion criteria

• Urinary tract infection or uropathogen within the past 12 months
• Serious medical problems
• NIH consensus exclusion criteria13 (presence of active urethritis, urogenital cancer, urinary tract disease, functionally significant urethral stricture, neurological disease affecting the bladder, etc.)
• Drug therapy that might affect lower urinary tract functions within the past 3 months