Clinical Evaluation, Biomarkers and Metabolomics of Sarcopenia in Frail Older Adults at Ambulatory Clinics (EC0991002-E)

National Taiwan University

Status: Unknown

Conditions: Frailty; Sarcopenia

Study type: Observational

Funder types: Other

Identifiers

NCT02073370

EC0991002-E (Registry Identifier)

201010021R

Details and patient eligibility

About

Sarcopenia related mobility dysfunction was a preventable presentation in transitional variation of frailty. However, the definition, associated risk factors, clinical course and outcome of sarcopenia in Taiwanese older adults are still under-clarified and need for further study.

Enrollment: 350 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• functional decline in recent one year
• cognitive impairment
• depressive symptom
• mobility impairment
• fall in recent one year
• eating or feeding problems
• weight loss
• co-morbid conditions≧5
• tracking by different physician ≧3 in recent half year
• poly-pharmacy≧8 in recent 3 months
• hospitalization ≧1 in recent one year
• emergency visits≧2 in recent one year
• aged ≧ 80.

Exclusion criteria

• non-ambulatory (bed-ridden) patients
• long-term residents at nursing homes
• patients with a life expectancy shorter than six months
• impairment in vision, hearing, or communicative ability, making convenience of clinical evaluation during the study period impossible.

Trial design

350 participants in 1 patient group

health subjects; outpatients aged over 65

Description:

The research subjects will be culled from outpatients aged over 65 at NTUH; 1000 Taiwanese subjects aged 20-40 equally divided in both genders will be recruited in order to establish the norm of Taiwanese's skeletal muscle index.