Clinical Evaluation of Chronic Consciousness Disorders Using Resting-state EEG and ERP

Zhejiang University

Status: Enrolling

Conditions: Disorders of Consciousness

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05949528

EEG assessment

Details and patient eligibility

About

Currently, there are significant challenges in the clinical assessment of patients with consciousness disorders, such as distinguishing between vegetative state (VS) and minimally conscious state (MCS), and predicting patient prognosis. This study aims to utilize different research techniques, such as auditory stimulation, as well as modified microstate methods, to enhance the disease classification and prognosis prediction of patients with chronic consciousness disorders.

Full description

The investigators collected resting-state electroencephalograms (EEGs) and EEGs under various event-related potential (ERP) stimuli from patients with chronic consciousness disorders, and performed analyses on these data. The resting-state EEGs were subjected to spectral analysis and microstate analysis. The ERP EEGs were analyzed in the time domain, as well as for phase coupling and other measures.Using these computed indicators, the investigators use machine learning, deep learning, and other methods to predict disease classification and prognosis assessment in patients with chronic consciousness disorders.

Enrollment: 200 estimated patients

Sex: All

Ages: 40 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients diagnosed with COMA /VS/MCS
2. The course of disease was more than 4 weeks
3. The vital signs were stable and able to tolerate the test process
4. Complete skull
5. Right-handed, no history of ear disease or hearing loss before onset

Exclusion criteria

1. History of epilepsy
2. Sedatives
3. Muscle relaxants and epileptic prophylaxis within 24 hours

Trial design

200 participants in 4 patient groups

Healthy controls (HCs)

Description:

Healthy controls (HCs)

Treatment:

Other: no intervention

Emerged from Minimally Conscious State (EMCS)

Description:

Emerged from Minimally Conscious State (EMCS): recovery of functional object uses or communication from chronic

Treatment:

Other: no intervention

Minimally conscious state (MCS)

Description:

Minimally conscious state (MCS): have reproducible signs of awareness and exhibit fluctuations in consciousness

Treatment:

Other: no intervention

Vegetative state (VS)

Description:

Vegetative state (VS): can open their eyes and preserve sleep-wake cycles, but unaware of themselves and their surroundings

Treatment:

Other: no intervention