Clinical Evaluation of Giomer Based Varnish Versus CPP-ACP Varnish in the Management of Dentin Hypersensitivity: a Randomized Clinical Trial

Cairo University (CU)

Status: Enrolling

Conditions: Dentin Hypersensitivity

Treatments: Procedure: Giomer Varnish; Procedure: CPP-ACP varnish

Study type: Interventional

Funder types: Other

Identifiers

NCT06154941

Giomer-CPPACP-Varnish

Details and patient eligibility

About

Dentin hypersensitivity is a drastic problem, which threaten many dental patients. According to the last published systematic review and meta analysis at 2019, the prevalence of dentin hypersensitivity is being 33.5% among the population. Moreover, it was determined that young adults with age range from 18 to 44 years exhibited high percentage (43.9%) of such problem

Full description

Several approaches to dentin hypersensitivity treatment were proposed to interfere, whether transiently or permanently, with the hydrodynamic theory. These approaches include root coverage and the use of lasers, ions, dentinal sealants, and occluding and nerve depolarization agents, chosen according to the primary cause. There are two major strategies in managing DH; the first is nerve desensitization, and the second is the physical occlusion of the patent tubule. The second approach can be carried out through a wide range of treatment modalities, including the use of proteins, salts or ions to plug the tubules. Many agents introduced are capable of sealing dentinal tubules, and can be used to reduce sensitivity. Of these agents are CPP-ACP varnish and the newly introduced giomer based varnish wilth S-PRG technology

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participants of both genders aged 18 to 40 years with good oral hygiene, suffering from pain due to dentin hypersensitivity in at least one tooth

Exclusion criteria

• Taking desensitizing treatment in the last 6 months. (It affects the outcome)

  • Taking anti-inflammatory drugs. (It affects the hypersensitivity perception)
  • Pregnant females. ( They complain from nausea and repeated vomiting attacks)
  • Smokers. (Smoking will affect the oral hygiene and periodontal health)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Giomer based Varnish

Experimental group

Treatment:

Procedure: Giomer Varnish

CPP-ACP based varnish

Active Comparator group

Treatment:

Procedure: CPP-ACP varnish