Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR

London School of Hygiene and Tropical Medicine

Status and phase: Unknown; Phase 3

Conditions: Japanese Encephalitis; Dengue; Malaria

Treatments: Drug: placebo control; Drug: 20% deet insect repellent

Study type: Interventional

Funder types: Other

Identifiers

NCT00938379

NHLAO1

Details and patient eligibility

About

Rural communities involved in agriculture are often at highest risk of insect-borne diseases in Southeast (SE) Asia.

Skin-applied insect repellents may prove a useful means of reducing mosquito-borne diseases for those people working outdoors in high risk areas.

This trial is evaluating the use of insect repellent (20% diethyltoluamide) to reduce incidence of malaria, Japanese Encephalitis and Dengue. The investigators will recruit up to 1000 households from 100 villages in rural Laos. In each house the investigators shall recruit up to 5 individuals. Half of households will be randomised to repellent, half to a placebo. All individuals will be provided with insecticide treated bed nets for use at night. All household occupants will be followed for 7 months to record malaria cases by Rapid Diagnostic Test every month. Blood spots will be collected at start and end of study to measure Japanese Encephalitis and Dengue. All positive cases will be promptly treated. Outcome will be reduction in number of malaria cases (primary outcome) and Dengue/Japanese Encephalitis (secondary outcomes).

Enrollment: 5,000 estimated patients

Sex: All

Ages: 5 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• working in agriculture
• available for monthly follow-up

Exclusion criteria

• allergy to repellent
• pregnant / breastfeeding

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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5,000 participants in 2 patient groups, including a placebo group

20% deet insect repellent

Experimental group

Description:

experimental intervention

Treatment:

Drug: 20% deet insect repellent

lotion without repellent active

Placebo Comparator group

Treatment:

Drug: placebo control