Clinical Evaluation of Topical Coenzyme Q10 in Management of Oral Aphthous Ulcer

Cairo University (CU)

Status: Unknown

Conditions: Oral Aphthous Ulcer

Treatments: Drug: Carpabol gel; Drug: topical coenzyme Q10 gel

Study type: Interventional

Funder types: Other

Identifiers

NCT03213769

1990 (Other Identifier)

Details and patient eligibility

About

Recurrent oral aphthous ulcer is the most common oral lesion in occurrence and one of cause is oxidative stress so investigators need to use antioxidant drugs like topical coenzyme Q10 gel to treat the lesion and more safe for the participants.

Full description

Double randomized clinical trial study using two parallel group suffer from oral aphthous ulcer one take antioxidant topical q10gel and other group take placebo carpabol gel two times per day for seven days measuring outcome at fourth and seventh day including pain; healing period and clinical parameters.

Sample size of study include 26 in each group.

Enrollment: 52 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with free medical history and no systemic diseases16.
• Patients clinically diagnosed as suffering from symptomatic oral minor aphthous ulcers.
• Patients who agreed to take medications.

Exclusion criteria

• Patients suffering from any systemic disease as Crohn's disease, Behcet's disease and others.
• Anemic and leukemic patients (using complete blood count investigation)
• Patients taking systemic drugs such as systemic steroids and other immunosuppressive therapy.
• Patients treated with any oral topical medications 48h before the study27.
• Pregnant and lactating mothers.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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52 participants in 2 patient groups, including a placebo group

topical coenzyme Q10 gel

Active Comparator group

Description:

Q10 gel will give 2 times /day after breakfast and evening meal for 7 days.

Treatment:

Drug: topical coenzyme Q10 gel

carbapol gel

Placebo Comparator group

Description:

placebo carbapol gel will give 2 times /day after breakfast and evening meal for 7 days.

Treatment:

Drug: Carpabol gel