Clinical Features and Outcome of Wilson's Disease With Generalized Epilepsy in Chinese Patients

Zhejiang University

Status: Completed

Conditions: Generalized Epilepsy; Wilson Disease

Treatments: Genetic: genetic test

Study type: Observational

Funder types: Other

Identifiers

NCT04965571

WD-seizures

Details and patient eligibility

About

Generalized epilepsy is rarely reported in patients with Wilson disease (WD) and lacks experience in clinical practice. We aim to provide better experience for the diagnosis and treatment for WD patients with epilepsy in the future.

Full description

A retrospective study was performed in 13 Chinese WD patients with generalized epilepsy. Each patient was diagnosed with WD by clinical evaluation and genetic screening. Patients were given small doses of antiepileptic drugs (AEDs), followed by copper-chelation therapy when the seizures stabilized. Clinical manifestations, brain imaging changes, and treatment and outcome after a long-term follow-up were analyzed.

Enrollment: 13 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Each patient was diagnosed with WD by clinical evaluation and genetic screening and had ever experienced generalized epilepsy

Exclusion criteria

• Not WD & without generalized epilepsy

Trial design

13 participants in 1 patient group

WD-seizures

Description:

Chinese WD patients with generalized epilepsy

Treatment:

Genetic: genetic test