Clinical Features and Outcomes of CBP Versus Non-CBP in Septic Children

Fudan University

Status: Enrolling

Conditions: Children, Only; Sepsis

Treatments: Procedure: CBP

Study type: Observational

Funder types: Other

Identifiers

NCT04794595

fdpicu-08

Details and patient eligibility

About

The effect of continuous blood purification (CBP) in children is unclear. Also, the timing of early application is still being explored. In this study, we need to explore the efficacy and the timing of application of CBP in children with sepsis or septic shock.

Full description

Early intervention of CBP can remove inflammatory factors in patients with sepsis and reduce the damage of inflammatory factors to organs; at the same time, it can also promote the body's immune response, significantly improve immune dysfunction, and restore the body's immune balance. However, the timing of early application of CBP in childhood sepsis is still unclear. Therefore, it is necessary to further explore the treatment and prognosis of this technology in the early treatment of sepsis.

Enrollment: 90 estimated patients

Sex: All

Ages: 28 days to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age of 29d to 18 years old;
• Children diagnosed with sepsis requiring blood purification.

Exclusion criteria

• with a history of a duration of PICU stay <24 h
• active bleeding, including cerebral hemorrhage

Trial design

90 participants in 2 patient groups

sepsis group with CBP

Description:

The child with sepsis should be treated with CBP， but could not receive this treatment for various reasons

Treatment:

Procedure: CBP

sepsis group without CBP

Description:

The child with sepsis should be treated with CBP and received this treatment