Clinical Features and Prognostic Markers in Adult Patients With AE Requiring ICU Treatment

Central South University

Status: Not yet enrolling

Conditions: Autoimmune Encephalitis

Treatments: Other: None, non-interventional study

Study type: Observational

Funder types: Other

Identifiers

NCT06456736

Xiangya_critical AE

Details and patient eligibility

About

Autoimmune encephalitis (AE) is a potentially life-threatening inflammation of the central nervous system (CNS) and constitutes 20%-30% of encephalitis cases in adults AE often leads to subacute, severe, and debilitating encephalitis necessitating long-term management in a neurologic intensive care unit (ICU). This study aims to explore the predictive factors for poor clinical outcomes by analyzing the clinical characteristics and prognosis of adult patients with critical AE requiring ICU admission. Prospective observational single center study in neurologic ICU, the second Xiangya hospital, Central South University. All patients admitted to the ICU for probable or confirmed AE (2022 Chinese guidelines for diagnosis and treatment of AE) will be included. Factors associated with a poor prognosis will be identified by multivariate analysis using a logistic regression.

Enrollment: 200 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed as either ''definite'' or ''probable'' AE based on Chinese guidelines for diagnosis and treatment of AE (version 2022)
• Age ≥ 15 years
• Admission to an adult ICU during the course of the disease

Exclusion criteria

• Missing data on primary outcome
• ICU length of stay of 24 hours or less.